The Artificial Induction of Subcutaneous Nodules in Patients with Rheumatic Fever.
نویسندگان
چکیده
Although subcutaneous nodules in subjects with rheumatic fever were described prior to the report of Barlow and Warner (1), these workers presented the first series of observations on 27 patients and described the clinical characteristics of nodules. Like Cheadle (2), these observers believed subcutaneous nodules to be diagnostic of rheumatic fever. The early literature has been adequately summarized by Futcher (3), and McEwen (4) has recently reviewed the more recent reports. Subcutaneous nodules are usually multiple and may appear in cr.ops over the bony prominences and sometimes on tendons. They are painless, non-tender, vary considerably in both size and consistency, and may be present from a few days to several months. Nodules are most apt to occur in patients with the more severe forms of rheumatic heart disease and many observers consider them to indicate a grave prognosis. Drewitt (5) first hypothesized that trauma was involved in the production of subcutaneous nodules because of their common occurrence over bony prominences. In confirming the many observations on the location of subcutaneous nodules, we were impressed with the possibility that trauma may be a factor in their appearance. Interest in such a probability resulted in an attempt to traumatize the elbows of rheumatic fever subjects by several methods to see if subcutaneous nodules could be artificially induced. The results of these attempts to reproduce subcutaneous nodules form the basis of the present report.
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عنوان ژورنال:
- The Journal of clinical investigation
دوره 16 1 شماره
صفحات -
تاریخ انتشار 1937